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Glioblastoma
Patients with glioblastoma has a 5 year survival rate of less than 5% after disease diagnosis. There is an urgent need to develop novel strategies to improve treatment outcomes for this deadly disease. Kancure has 2 pipelines 3 pipelines that is currently under preclinical developemnt.
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Targeting E3 Ligases
E3 ligases are responsible for rapid protein turnover in human malignancies and are therefore often upregulated. We are developing technologies to either directly inhibit E3 ligases or harnessing the protein-degradating power of E3 Ligases in downregulating certain oncogenic proteins
OUR SOLUTIONS
PROTACs in Radiosensitization
Kancure is developing PROTACs that can cross blood brain barrier (BBB) to treat CNS diseases such as primary brain tumor, brain metastasis, and degenerative brain diseases.
E3 Ligases in Human Diseases
Our leading PROTACs can penetrate BBB and can target degradation of key pro-survival proteins in glioma. Also, we are developing developing platforms by designing and synthesizing new E3 ligases ligands/inhibitors.
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Radiotherapy
Over 50% cancer patients will need radiotherapy during their course of treatment. Kancure is developing neural networks that can guide radiotherapy treatment planning. Kancure is also developing herbal based compounds for prevention and alleviation of radiodermatitis.